Combined pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG) is an extremely rare tumor, with fewer than 20 cases reported. The authors report a case of combined PXA-GG in an 18-year-old man with a history of seizures. The tumor showed necrosis and the BRAF V600E mutation on histological examination, with no evidence of tumor recurrence 1 year after gross-total resection. The BRAF V600E mutation was present, which suggests that both cell lineages may share a common cellular origin.
Keywords: BRAF mutation; GFAP = glial fibrillary acidic protein; GG = ganglioglioma; PCR = polymerase chain reaction; PXA = pleomorphic xanthoastrocytoma; combined pleomorphic xanthoastrocytoma-ganglioglioma; ganglioglioma; oncology; pleomorphic xanthoastrocytoma.