In this research, antibacterial effects of two cavity varnishes (Copalite and Espe), two bonding agents (Scotchbond and Adaptabond), and Delton fissure sealent, on the various microorganisms that are predominant in the oral bacterial flora, has been investigated invitro. The maximum antibacterial effect upon all the tested microorganisms has been found with Scotchbond. The other agents listed in decreasing order of effectiveness were, Copalite, Espe varnish and Adaptabond. Delton fissur sealent found to have the least measurable antimicrobial action.