Various simultaneous nail changes due to valproic acid use

Cutan Ocul Toxicol. 2017 Mar;36(1):96-97. doi: 10.3109/15569527.2016.1156121. Epub 2016 Mar 17.

Abstract

There are only a few case reports about nail changes due to valproic acid in the literature despite its widespread use. We present a 50-year-old man who had onycholysis, roughness of the nail surface and brownish-yellow discoloration of both fingernails and toenails, which remarkably ameliorated upon cessation of valproic acid.

Keywords: Antiepileptic; drug; nail; onycholysis; valproic acid.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / adverse effects*
  • Epilepsy / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Nails / drug effects*
  • Pigmentation / drug effects
  • Valproic Acid / adverse effects*

Substances

  • Anticonvulsants
  • Valproic Acid