Autoimmune disease-associated gene expression is reduced by BET-inhibition

Janneke G C Peeters; Stephin J Vervoort; Gerdien Mijnheer; Sytze de Roock; Sebastiaan J Vastert; Edward E S Nieuwenhuis; Femke van Wijk; Berent J Prakken; Michal Mokry; Jorg van Loosdregt

doi:10.1016/j.gdata.2015.11.004

Autoimmune disease-associated gene expression is reduced by BET-inhibition

Genom Data. 2015 Nov 7:7:14-7. doi: 10.1016/j.gdata.2015.11.004. eCollection 2016 Mar.

Affiliations

¹ Dept. of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
² Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands; Division of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht 3584 EA, The Netherlands.
³ Division of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht 3584 EA, The Netherlands.
⁴ Dept. of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht 3508 GA, The Netherlands; Division of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht 3584 EA, The Netherlands.

Abstract

For many autoimmune diseases, the underlying mechanism is still unknown. In order to get more insight into the etiology of autoimmune diseases, we recently published a study were we performed epigenetic profiling and RNA sequencing on CD4(+)CD45RO(+) T cells derived from the site of inflammation of Juvenile Idiopathic Arthritis (JIA) patients and compared this with healthy controls [1]. In this "Data in Brief", we focus on the analysis of our RNA sequencing data reported in this study, of which the raw and processed files can be found in GEO under GSE71595. We provide a detailed description of the downstream analysis, quality controls, and different analysis methods or techniques that validate the results obtained with RNA-sequencing.

Keywords: Autoimmune disease; BET-inhibition; Juvenile Idiopathic Arthritis; RNA-sequencing.