Endothelin-1 as a predictor of impaired glucose tolerance and type 2 diabetes--A longitudinal study in the Vara-Skövde Cohort

Josefin Olausson; Bledar Daka; Margareta I Hellgren; Charlotte A Larsson; Max Petzold; Ulf Lindblad; Per-Anders Jansson

doi:10.1016/j.diabres.2016.01.027

Endothelin-1 as a predictor of impaired glucose tolerance and type 2 diabetes--A longitudinal study in the Vara-Skövde Cohort

Diabetes Res Clin Pract. 2016 Mar:113:33-7. doi: 10.1016/j.diabres.2016.01.027. Epub 2016 Feb 2.

Authors

Josefin Olausson¹, Bledar Daka², Margareta I Hellgren³, Charlotte A Larsson⁴, Max Petzold⁵, Ulf Lindblad⁶, Per-Anders Jansson⁷

Affiliations

¹ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: josefin.olausson@wlab.gu.se.
² Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: bledar.daka@allmed.gu.se.
³ Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: margareta.leonardsson-hellgren@vgregion.se.
⁴ Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Social Medicine and Global Health, Department of Clinical Sciences, Malmö, Lund University, Sweden. Electronic address: charlotte_a.larsson@med.lu.se.
⁵ Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: max.petzold@gu.se.
⁶ Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: ulf.lindblad@gu.se.
⁷ The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address: per-anders.jansson@medic.gu.se.

PMID: 26972958
DOI: 10.1016/j.diabres.2016.01.027

Abstract

We addressed whether endothelin-1, a marker of endothelial dysfunction, predicts impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in a population study in south-western Sweden. Follow-up after 9.7 years showed an association between circulating endothelin-1 levels at baseline and development of IGT/T2DM in women but not in men.

Keywords: Endothelin-1; Impaired glucose tolerance; Sex differences; Skaraborg Project; Type 2 diabetes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers / blood*
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / diagnosis*
Diabetes Mellitus, Type 2 / epidemiology
Endothelin-1 / blood*
Female
Glucose Intolerance / blood
Glucose Intolerance / diagnosis*
Glucose Intolerance / epidemiology
Glucose Tolerance Test
Humans
Longitudinal Studies
Male
Middle Aged
Sweden / epidemiology

Substances

Biomarkers
Endothelin-1