Abstract
The tedizolid MIC of 27 clinical isolates of linezolid-resistant staphylococci and enterococci was determined. Tedizolid MICs were ≥1μg/mL and were 4- to 32-fold lower than those of linezolid. Linezolid resistance mechanisms included G2576T 23S rRNA gene and rplC and rplD mutations.
Keywords:
Antimicrobial resistance; Linezolid resistance; Multidrug resistance; Tedizolid resistance; Vancomycin resistant.
Copyright © 2016 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial*
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Enterococcus / drug effects*
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Enterococcus / genetics
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Humans
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Linezolid / pharmacology*
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Microbial Sensitivity Tests*
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Mutation
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Organophosphates / pharmacology*
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Oxazoles / pharmacology*
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RNA, Ribosomal, 23S / genetics
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Staphylococcus / drug effects*
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Staphylococcus / genetics
Substances
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Anti-Bacterial Agents
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Organophosphates
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Oxazoles
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RNA, Ribosomal, 23S
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Linezolid
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tedizolid phosphate