In vitro activity of tedizolid against linezolid-resistant staphylococci and enterococci

Diagn Microbiol Infect Dis. 2016 May;85(1):102-4. doi: 10.1016/j.diagmicrobio.2016.02.008. Epub 2016 Feb 9.

Abstract

The tedizolid MIC of 27 clinical isolates of linezolid-resistant staphylococci and enterococci was determined. Tedizolid MICs were ≥1μg/mL and were 4- to 32-fold lower than those of linezolid. Linezolid resistance mechanisms included G2576T 23S rRNA gene and rplC and rplD mutations.

Keywords: Antimicrobial resistance; Linezolid resistance; Multidrug resistance; Tedizolid resistance; Vancomycin resistant.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial*
  • Enterococcus / drug effects*
  • Enterococcus / genetics
  • Humans
  • Linezolid / pharmacology*
  • Microbial Sensitivity Tests*
  • Mutation
  • Organophosphates / pharmacology*
  • Oxazoles / pharmacology*
  • RNA, Ribosomal, 23S / genetics
  • Staphylococcus / drug effects*
  • Staphylococcus / genetics

Substances

  • Anti-Bacterial Agents
  • Organophosphates
  • Oxazoles
  • RNA, Ribosomal, 23S
  • Linezolid
  • tedizolid phosphate