Cancer Cell Membrane-Coated Upconversion Nanoprobes for Highly Specific Tumor Imaging

Lang Rao; Lin-Lin Bu; Bo Cai; Jun-Hua Xu; Andrew Li; Wen-Feng Zhang; Zhi-Jun Sun; Shi-Shang Guo; Wei Liu; Tza-Huei Wang; Xing-Zhong Zhao

doi:10.1002/adma.201506086

Cancer Cell Membrane-Coated Upconversion Nanoprobes for Highly Specific Tumor Imaging

Adv Mater. 2016 May;28(18):3460-6. doi: 10.1002/adma.201506086. Epub 2016 Mar 10.

Authors

Lang Rao¹, Lin-Lin Bu², Bo Cai¹, Jun-Hua Xu¹, Andrew Li³, Wen-Feng Zhang², Zhi-Jun Sun², Shi-Shang Guo¹, Wei Liu^{1

4}, Tza-Huei Wang^{3

4}, Xing-Zhong Zhao¹

Affiliations

¹ Key Laboratory of Artificial Micro- and Nano-Structuresof Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan, Hubei, 430072, China.
² Department of Oral Maxillofacial Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, 430079, China.
³ Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
⁴ Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

PMID: 26970518
DOI: 10.1002/adma.201506086

Abstract

Cancer cell membrane-coated upconversion nanoprobes (CC-UCNPs) with immune escape and homologous targeting capabilities are used for highly specific tumor imaging. The combination of UCNPs with biomimetic cancer cell membranes embodies a novel materials design strategy and presents a compelling class of advanced materials.

Keywords: cancer cell membranes; homologous targets; immune escape; tumor imaging; upconversion nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Membrane*
Humans
Nanoparticles
Neoplasms