AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

Chen-Song Zhang; Sheng-Cai Lin

doi:10.1016/j.cmet.2016.02.017

AMPK Promotes Autophagy by Facilitating Mitochondrial Fission

Cell Metab. 2016 Mar 8;23(3):399-401. doi: 10.1016/j.cmet.2016.02.017.

Authors

Chen-Song Zhang¹, Sheng-Cai Lin²

Affiliations

¹ State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.
² State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address: linsc@xmu.edu.cn.

PMID: 26959181
DOI: 10.1016/j.cmet.2016.02.017

Abstract

AMPK senses decreased cellular energy levels, triggering mitochondrial autophagy or mitophagy through activating ULK1 and inhibiting mTORC1. In a recent report, Toyama et al. (2016) show that activated AMPK phosphorylation of MFF is critical for mitochondrial fission. Unphosphorylatable MFF mutants block mitophagy, connecting AMPK to mitochondrial fission and to mitophagy.

Publication types

Comment

MeSH terms

AMP-Activated Protein Kinases / metabolism*
Energy Metabolism*
Humans
Mitochondria / physiology*
Mitochondrial Dynamics*
Stress, Physiological*

Substances

AMP-Activated Protein Kinases