Modified Polyacrylic Acid-Zinc Composites: Synthesis, Characterization and Biological Activity

Molecules. 2016 Feb 29;21(3):292. doi: 10.3390/molecules21030292.

Abstract

Polyacrylic acid (PAA) is an important industrial chemical, which has been extensively applied in various fields, including for several biomedical purposes. In this study, we report the synthesis and modification of this polymer with various phenol imides, such as succinimide, phthalimide and 1,8-naphthalimide. The as-synthesized derivatives were used to prepare polymer metal composites by the reaction with Zn(+2). These composites were characterized by using various techniques, including NMR, FT-IR, TGA, SEM and DSC. The as-prepared PAA-based composites were further evaluated for their anti-microbial properties against various pathogens, which include both Gram-positive and Gram-negative bacteria and different fungal strains. The synthesized composites have displayed considerable biocidal properties, ranging from mild to moderate activities against different strains tested.

Keywords: biological activity; metal composite; polyacrylic acid; zinc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemical synthesis*
  • Acrylic Resins / chemistry
  • Acrylic Resins / pharmacology*
  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Composite Resins / chemical synthesis
  • Composite Resins / chemistry
  • Composite Resins / pharmacology
  • Fungi / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Magnetic Resonance Imaging
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Zinc / chemistry*

Substances

  • Acrylic Resins
  • Anti-Infective Agents
  • Composite Resins
  • carbopol 940
  • Zinc