Anti-VEGF and its impact on the outer retina: retinal pigment epithelium tear after an injection of aflibercept in contralateral eye

Arch Soc Esp Oftalmol. 2016 May;91(5):245-9. doi: 10.1016/j.oftal.2016.01.001. Epub 2016 Feb 15.
[Article in English, Spanish]

Abstract

Case report: A 62-year-old woman with a history of bilateral retinal pigment epithelium detachment (PED), secondary of age-related macular degeneration (AMD), who presented with a retinal pigment epithelium (RPE) tear on her left eye after an aflibercept injection in the contralateral eye one month earlier.

Discussion: A RPE tear is the main complication when the anti-VEGF therapy is used for the management of the PED. Furthermore, it should be noted that systemic absorption of the drug can induce an effect on the untreated eye.

Keywords: Aflibercept; Age-related macular degeneration; Anti-VEGF; Degeneración macular asociada a la edad; Desprendimiento del epitelio pigmentario de la retina; Retinal pigment epithelium detachment; Retinal pigment epithelium tear; Rotura del epitelio pigmentario de la retina.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Injections, Intraocular
  • Middle Aged
  • Receptors, Vascular Endothelial Growth Factor / administration & dosage
  • Receptors, Vascular Endothelial Growth Factor / antagonists & inhibitors*
  • Recombinant Fusion Proteins / administration & dosage
  • Recombinant Fusion Proteins / adverse effects*
  • Retinal Pigment Epithelium / injuries*

Substances

  • Recombinant Fusion Proteins
  • aflibercept
  • Receptors, Vascular Endothelial Growth Factor