Novel Feline Leukemia Virus Interference Group Based on the env Gene

Ariko Miyake; Shinya Watanabe; Takahiro Hiratsuka; Jumpei Ito; Minh Ha Ngo; Isaac Makundi; Junna Kawasaki; Yasuyuki Endo; Hajime Tsujimoto; Kazuo Nishigaki

doi:10.1128/JVI.03229-15

Novel Feline Leukemia Virus Interference Group Based on the env Gene

J Virol. 2016 Apr 14;90(9):4832-4837. doi: 10.1128/JVI.03229-15. Print 2016 May.

Authors

Affiliations

¹ Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan.
² Laboratory of Small Animal Internal Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
³ Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
⁴ Laboratory of Molecular Immunology and Infectious Disease, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan kaz@yamaguchi-u.ac.jp.

Abstract

Feline leukemia virus (FeLV) subgroups have emerged in infected cats via the mutation or recombination of the env gene of subgroup A FeLV (FeLV-A), the primary virus. We report the isolation and characterization of a novel env gene, TG35-2, and report that the TG35-2 pseudotype can be categorized as a novel FeLV subgroup. The TG35-2 envelope protein displays strong sequence identity to FeLV-A Env, suggesting that selection pressure in cats causes novel FeLV subgroups to emerge.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Cats
Cell Line
Cells, Cultured
Humans
Leukemia Virus, Feline / physiology*
Molecular Sequence Data
Protein Binding
Protein Interaction Domains and Motifs
Receptors, Virus / metabolism
Sequence Alignment
Viral Envelope Proteins / chemistry
Viral Envelope Proteins / genetics*
Viral Interference*
Viral Tropism
Virus Replication

Substances

Receptors, Virus
Viral Envelope Proteins