Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

J Neuroimmunol. 2016 Feb 15:291:1-10. doi: 10.1016/j.jneuroim.2015.11.026. Epub 2015 Dec 2.

Abstract

Japanese macaque encephalomyelitis (JME) is an inflammatory demyelinating disease that occurs spontaneously in a colony of Japanese macaques (JM) at the Oregon National Primate Research Center. Animals with JME display clinical signs resembling multiple sclerosis (MS), and magnetic resonance imaging reveals multiple T2-weighted hyperintensities and gadolinium-enhancing lesions in the central nervous system (CNS). Here we undertook studies to determine if JME possesses features of an immune-mediated disease in the CNS. Comparable to MS, the CNS of animals with JME contain active lesions positive for IL-17, CD4+ T cells with Th1 and Th17 phenotypes, CD8+ T cells, and positive CSF findings.

Keywords: Demyelination; Inflammatory; Interleukin 17 (IL-17); Intrathecal IgG; Magnetic resonance imaging (MRI); Th1; Th17.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antigens, CD / metabolism
  • B-Lymphocytes / metabolism
  • B-Lymphocytes / pathology
  • Central Nervous System / pathology*
  • Cytokines / metabolism
  • Disease Models, Animal
  • Encephalomyelitis / embryology*
  • Encephalomyelitis / pathology*
  • Lymphocytes / metabolism
  • Lymphocytes / pathology
  • Macaca
  • Macrophages / metabolism
  • Macrophages / pathology
  • Magnetic Resonance Imaging
  • Microfilament Proteins / metabolism
  • Microglia / metabolism
  • Microglia / pathology
  • Multiple Sclerosis / immunology*
  • Multiple Sclerosis / pathology*
  • Myelin Basic Protein / metabolism
  • Nerve Tissue Proteins / metabolism

Substances

  • Antigens, CD
  • Cytokines
  • Microfilament Proteins
  • Myelin Basic Protein
  • Nerve Tissue Proteins