Use of a Loading Dose of Vitamin D for Treatment of Vitamin D Deficiency in Patients With Intestinal Failure

Neil Grenade; Christina Kosar; Karen Steinberg; Yaron Avitzur; Paul W Wales; Glenda Courtney-Martin

doi:10.1177/0148607115625220

Use of a Loading Dose of Vitamin D for Treatment of Vitamin D Deficiency in Patients With Intestinal Failure

JPEN J Parenter Enteral Nutr. 2017 Mar;41(3):512-516. doi: 10.1177/0148607115625220. Epub 2016 Jul 11.

Authors

Neil Grenade¹, Christina Kosar^{1

2}, Karen Steinberg^{1

2}, Yaron Avitzur^{1

2

3}, Paul W Wales^{1

2

4}, Glenda Courtney-Martin^{1

2

5}

Affiliations

¹ 1 Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
² 2 Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada.
³ 3 Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
⁴ 4 Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
⁵ 5 Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada.

PMID: 26826260
DOI: 10.1177/0148607115625220

Abstract

Vitamin D deficiency is common in patients with intestinal failure and short bowel syndrome who have been weaned of parenteral nutrition. Dietary supplementation with vitamin D is necessary to correct this deficiency. In certain cases, routine supplementation strategy may be ineffective. We report 3 cases of vitamin D deficiency in patients with intestinal failure who showed improvement in serum 25-hydroxyvitamin D levels after supplementation with a loading dose of 20,000-40,000 IU vitamin D provided weekly.

Keywords: intestinal failure; micronutrient malabsorption; pediatrics; vitamin D.

Publication types

Case Reports

MeSH terms

Child
Child, Preschool
Dietary Supplements
Dose-Response Relationship, Drug
Humans
Male
Short Bowel Syndrome / complications
Short Bowel Syndrome / drug therapy*
Vitamin D / administration & dosage*
Vitamin D / blood
Vitamin D Deficiency / blood
Vitamin D Deficiency / drug therapy*
Vitamin D Deficiency / etiology

Substances

Vitamin D