Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes

Cell. 2016 Jan 28;164(3):349-52. doi: 10.1016/j.cell.2015.12.027.

Abstract

Type I interferon (IFN-I) elicits a complex cascade of events in response to microbial infection. Here, we review recent developments illuminating the large number of IFN-I species and describing their unique biologic functions.

Keywords: bacterial infection; interferon alpha-beta receptor; interferon-alpha; interferon-beta; pathogenesis; persistent viral infection; type 1 interferon.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Humans
  • Interferon Type I / chemistry
  • Interferon Type I / immunology
  • Interferon Type I / metabolism*
  • Receptor, Interferon alpha-beta / metabolism
  • Virus Diseases / immunology*
  • Virus Diseases / virology

Substances

  • Interferon Type I
  • Receptor, Interferon alpha-beta