We experienced a surgical correction of isolated infundibular pulmonary stenosis (IIPS) of a 50-year-old male patient. The infundibular tissue was resected by the transpulmonary approach, and no trace of ventricular septal defect was found. There was a couple of pouch-like structure in the infundibular chamber of the right ventricle. The etiology of this structure was likely to be related turbulence as blood was ejected from the right ventricle to the infundibular chamber. Surgical correction of IIPS over 50 years old had been rarely reported. In addition, it was the first case report of IIPS with pouch of the infundibular chamber.