The Growing Spectrum of Cutaneous RASopathy

J Invest Dermatol. 2016 Feb;136(2):359-360. doi: 10.1016/j.jid.2015.10.059.

Abstract

Groesser et al. demonstrate that pyogenic granuloma is a RAS pathway-driven tumor. This important observation adds yet another manifestation to the growing spectrum of cutaneous "RASopathies" and raises intriguing questions about the relationship between RAS pathway activation and malignancy.

Publication types

  • Comment

MeSH terms

  • Female
  • Genes, ras / genetics*
  • Genetic Predisposition to Disease*
  • Granuloma, Pyogenic / genetics*
  • Humans
  • Male
  • Proto-Oncogene Proteins B-raf / genetics*
  • Skin Diseases / genetics*

Substances

  • Proto-Oncogene Proteins B-raf