Isodicentric Philadelphia chromosome: an uncommon chromosomal abnormality in the chronic phase of chronic myeloid leukemia (CML)

Eric Loo; Pranshu Bansal; Durga Cherukuri; Cecilia Arana Yi

doi:10.1002/ccr3.444

Isodicentric Philadelphia chromosome: an uncommon chromosomal abnormality in the chronic phase of chronic myeloid leukemia (CML)

Clin Case Rep. 2015 Nov 19;4(1):43-5. doi: 10.1002/ccr3.444. eCollection 2016 Jan.

Authors

Eric Loo¹, Pranshu Bansal², Durga Cherukuri¹, Cecilia Arana Yi²

Affiliations

¹ Department of Pathology University of New Mexico Albuquerque New Mexico.
² Department of Medicine University of New Mexico Albuquerque New Mexico.

Abstract

An isodicentric Philadelphia chromosome is an uncommon finding previously described as a secondary chromosomal abnormality in accelerated- or blast-phase of chronic myeloid leukemia (CML) with resistance to imatinib mesylate or dasatinib. Here, we present a case with idic(Ph) chromosome identified at initial diagnosis in a patient with chronic-phase CML.

Keywords: CML; cytogenetics; isodicentric; philadelphia chromosome.

Publication types

Case Reports