Detection of weak hydrogen bonding to fluoro and nitro groups in solution using H/D exchange

Org Biomol Chem. 2016 Feb 21;14(7):2223-7. doi: 10.1039/c5ob02360b. Epub 2016 Jan 19.

Abstract

Hydrogen/deuterium (H/D) exchange can be a sensitive technique for measuring the strength of hydrogen bonding to neutral organic nitro and fluoro groups. The slower rates of reaction in comparison to suitable controls suggest that hydrogen bonding is present, albeit rather weak.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.