Spatial Sequence Coding Differs during Slow and Fast Gamma Rhythms in the Hippocampus

Chenguang Zheng; Kevin Wood Bieri; Yi-Tse Hsiao; Laura Lee Colgin

doi:10.1016/j.neuron.2015.12.005

Spatial Sequence Coding Differs during Slow and Fast Gamma Rhythms in the Hippocampus

Neuron. 2016 Jan 20;89(2):398-408. doi: 10.1016/j.neuron.2015.12.005. Epub 2016 Jan 7.

Authors

Chenguang Zheng¹, Kevin Wood Bieri², Yi-Tse Hsiao³, Laura Lee Colgin⁴

Affiliations

¹ Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712-0805, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712-0805, USA. Electronic address: cgzhengnk@gmail.com.
² Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712-0805, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712-0805, USA.
³ Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712-0805, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712-0805, USA.
⁴ Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712-0805, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712-0805, USA; Department of Neuroscience, University of Texas at Austin, Austin, TX 78712-0805, USA. Electronic address: colgin@mail.clm.utexas.edu.

Abstract

Spatiotemporal trajectories are coded by "theta sequences," ordered series of hippocampal place cell spikes that reflect the order of behavioral experiences. Theta sequences are thought to be organized by co-occurring gamma rhythms (∼25-100 Hz). However, how sequences of locations are represented during distinct slow (∼25-55 Hz) and fast (∼60-100 Hz) gamma subtypes remains poorly understood. We found that slow gamma-associated theta sequences activated on a compressed timescale and represented relatively long paths extending ahead of the current location. Fast gamma-associated theta sequences more closely followed an animal's actual location in real time. When slow gamma occurred, sequences of locations were represented across successive slow gamma phases. Conversely, fast gamma phase coding of spatial sequences was not observed. These findings suggest that slow gamma promotes activation of temporally compressed representations of upcoming trajectories, whereas fast gamma supports coding of ongoing trajectories in real time.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Action Potentials / physiology*
Animals
Gamma Rhythm / physiology*
Hippocampus / physiology*
Male
Rats
Rats, Long-Evans
Theta Rhythm / physiology*

Abstract

Publication types

MeSH terms

Grants and funding