The LAST Project and the diagnostic bottom line

Cytopathology. 2015 Dec;26(6):343-5. doi: 10.1111/cyt.12299.

Abstract

The LAST Project's consensus recommendations for terminology and biomarker use to improve the accuracy and reproducibility of histopathological diagnoses for HPV-associated squamous intraepithelial lesions of the lower anogenital tract are reviewed.

Keywords: HPV; p16; squamous intraepithelial lesions; terminology.

Publication types

  • Review

MeSH terms

  • Anal Canal / pathology
  • Anus Neoplasms / classification*
  • Anus Neoplasms / pathology
  • Biomarkers
  • Cervix Uteri / cytology
  • Cervix Uteri / pathology
  • Cyclin-Dependent Kinase Inhibitor p16
  • Eosine Yellowish-(YS)
  • Female
  • Fluorescent Dyes
  • Hematoxylin
  • Humans
  • Neoplasm Proteins / immunology
  • Papillomavirus Infections / classification*
  • Papillomavirus Infections / pathology
  • Reproducibility of Results
  • Squamous Intraepithelial Lesions of the Cervix / classification*
  • Squamous Intraepithelial Lesions of the Cervix / pathology
  • Terminology as Topic*

Substances

  • Biomarkers
  • CDKN2A protein, human
  • Cyclin-Dependent Kinase Inhibitor p16
  • Fluorescent Dyes
  • Neoplasm Proteins
  • Eosine Yellowish-(YS)
  • Hematoxylin