Retrospective comparison of thromboelastography results to postmortem evidence of thrombosis in critically ill dogs: 39 cases (2005-2010)

J Vet Emerg Crit Care (San Antonio). 2016 May;26(3):428-36. doi: 10.1111/vec.12441. Epub 2016 Jan 8.

Abstract

Objective: To determine whether there is an association between thromboelastography (TEG) data and necropsy evidence of thrombosis in a cohort of critically ill dogs.

Design: Retrospective study (2005-2010).

Setting: University teaching hospital.

Animals: Thirty-nine client-owned critically ill dogs for which TEG was performed within 7 days of complete necropsy.

Interventions: None.

Measurements and main results: Thrombi were found in 26 (67%) dogs. Spayed females (n = 20) were significantly more likely to have thrombosis (P = 0.0127). No significant association was found between presence of thrombosis and any TEG parameter, the calculated coagulation index, results of coagulation testing, type of vascular access, or clinical diagnosis. D-dimers were significantly higher in dogs with thrombosis (P = 0.0207) and a weak positive correlation was found between D-dimer value and number of sites of thrombosis (ρ = 0.18, P = 0.0045). Dogs with WBC > 16 × 10(3) /μL were more likely to have thrombosis compared to others (odds ratio 5.56, 95% confidence interval 1.2-25.7, P = 0.025).

Conclusions: This study found no association between any TEG parameter and the presence of thrombosis on postmortem examination.

Keywords: DIC; TEG; coagulopathy; disseminated intravascular coagulation; hypercoagulable; viscoelastic testing.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Autopsy
  • Cohort Studies
  • Critical Illness*
  • Dog Diseases / blood
  • Dog Diseases / diagnosis*
  • Dog Diseases / pathology
  • Dogs
  • Female
  • Fibrin Fibrinogen Degradation Products
  • Hospitals, University
  • Male
  • Medical Records
  • Retrospective Studies
  • Thrombelastography / veterinary
  • Thrombosis / diagnosis
  • Thrombosis / veterinary*

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D