Blurred Boundaries: The RNA Binding Protein Lin28A Is Also an Epigenetic Regulator

Frederick E Tan; Gene W Yeo

doi:10.1016/j.molcel.2015.12.018

Blurred Boundaries: The RNA Binding Protein Lin28A Is Also an Epigenetic Regulator

Mol Cell. 2016 Jan 7;61(1):1-2. doi: 10.1016/j.molcel.2015.12.018.

Authors

Frederick E Tan¹, Gene W Yeo²

Affiliations

¹ Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92037, USA; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92037, USA.
² Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92037, USA; Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92037, USA; Molecular Engineering Laboratory, A(∗)STAR, 138673 Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117549 Singapore, Singapore. Electronic address: geneyeo@ucsd.edu.

PMID: 26748607
DOI: 10.1016/j.molcel.2015.12.018

Abstract

Lin28A is best known as a post-transcriptional regulator of gene expression. In this issue, Zeng et al. (2016) show that Lin28A has an unexpected role as an epigenetic regulator of DNA.

Publication types

Comment

MeSH terms

Animals
DNA-Binding Proteins / metabolism*
Embryonic Stem Cells / metabolism*
Gene Expression Regulation*
Promoter Regions, Genetic*
Proto-Oncogene Proteins / metabolism*
RNA-Binding Proteins / metabolism*
Transcriptional Activation*

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins
RNA-Binding Proteins