Two new peroxy fatty acids with antibacterial activity from Ophioglossum thermale Kom

Fitoterapia. 2016 Mar:109:212-6. doi: 10.1016/j.fitote.2015.12.019. Epub 2015 Dec 30.

Abstract

Two new peroxy fatty acids, thermalic acids A (1) and B (2), together with eight known compounds, (3β)-methyl-3-hydroxy-urs-11-en-28 oate (3), luteolin (4), quercetin (5), 3-methoxyquercetin (6), ophioglonol (7), ophioglonol 4'-O-α-D-glucopyranoside (8), pedunculosumoside B (9), syringol (10), were isolated from the herba of Ophioglossum thermale Kom. The structures of 1 and 2 were identified by HRESIMS, EIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) spectra. Both two acids exhibited potential antibacterial activities against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. This is the first report of peroxy fatty acids isolated from herbaceous plants of Ophioglossaceae.

Keywords: Antibacterial activity; Ophioglossum thermale Kom.; Peroxy fatty acid; Thermalic acid A; Thermalic acid B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Asteraceae / chemistry*
  • Dioxolanes / chemistry*
  • Dioxolanes / isolation & purification
  • Escherichia coli / drug effects
  • Fatty Acids / chemistry*
  • Fatty Acids / isolation & purification
  • Molecular Structure
  • Oleic Acids / chemistry*
  • Oleic Acids / isolation & purification
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Dioxolanes
  • Fatty Acids
  • Oleic Acids
  • thermalic acid A
  • thermalic acid B