Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock

Subrina Jesmin; Satoshi Gando; Takeshi Wada; Mineji Hayakawa; Atsushi Sawamura

doi:10.1186/s40560-015-0123-2

Activated protein C does not increase in the early phase of trauma with disseminated intravascular coagulation: comparison with acute coagulopathy of trauma-shock

J Intensive Care. 2016 Jan 4:4:1. doi: 10.1186/s40560-015-0123-2. eCollection 2016.

Authors

Subrina Jesmin¹, Satoshi Gando¹, Takeshi Wada¹, Mineji Hayakawa¹, Atsushi Sawamura¹

Affiliation

¹ Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo, 060-8638 Japan.

Abstract

We hypothesized that activated protein C does not increase in disseminated intravascular coagulation (DIC) after trauma and that the same is true for acute coagulopathy of trauma-shock (ACOTS). Activated protein C levels were prospectively measured in 57 trauma patients: 30 with DIC and 27 without DIC. Normal to more decreased activated protein C levels were observed in DIC patients than in the controls and non-DIC patients. The activated protein C levels in ACOTS patients were similar to those in DIC patients. In conclusion, activated protein C does not increase in either DIC or ACOTS in the early phase of trauma.

Keywords: Activated protein C; Coagulopathy; Disseminated intravascular coagulation (DIC); Trauma.