Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation

Haiqin Song; Xiang Kang; Jing Sun; Xiabin Jing; Zehua Wang; Lesan Yan; Ruogu Qi; Minhua Zheng

doi:10.1039/c5cc09534d

Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation

Chem Commun (Camb). 2016 Feb 7;52(11):2281-3. doi: 10.1039/c5cc09534d.

Authors

Haiqin Song¹, Xiang Kang², Jing Sun¹, Xiabin Jing³, Zehua Wang², Lesan Yan⁴, Ruogu Qi⁴, Minhua Zheng¹

Affiliations

¹ Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 People's Republic of China. zmhtiger@yeah.net and Shanghai Minimally Invasive Surgery Center, Shanghai, 200025 P. R. China.
² Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.
³ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China. Ruoguqix@gmail.com Lesanyan@gmail.com.
⁴ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China. Ruoguqix@gmail.com Lesanyan@gmail.com and The University of Chinese Academy of Sciences, Beijing 100049, China.

PMID: 26727577
DOI: 10.1039/c5cc09534d

Abstract

The introduction of a sterically hindered pyridine ligand to a photosensitive platinum(iv) drug for drug delivery resulted in a >100 fold increase in effectiveness compared to the gold standard, cisplatin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cisplatin / administration & dosage*
Light*
Nanoparticles*
Platinum Compounds / administration & dosage*
Prodrugs / administration & dosage*

Substances

Platinum Compounds
Prodrugs
Cisplatin