Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6

Bioorg Med Chem Lett. 2016 Jan 15;26(2):695-698. doi: 10.1016/j.bmcl.2015.11.035. Epub 2015 Nov 12.

Abstract

A library of boswellic acid analogues were synthesized and tested for their anti-inflammatory potential on key inflammatory mediators, TNF-α and IL-6. The study led to the identification of lead compounds showing significant inhibition of the cytokines, TNF-α and IL-6 both in vitro and in vivo.

Keywords: Anti-inflammatory; Cytokine; IL-6; TNF-α; β-Boswellic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology*
  • Humans
  • Interleukin-6 / antagonists & inhibitors*
  • Interleukin-6 / immunology
  • Mice
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Anti-Inflammatory Agents
  • Interleukin-6
  • Triterpenes
  • Tumor Necrosis Factor-alpha
  • boswellic acid