Achieving Tolerance with Perforin-Secreting Dendritic Cells

Trends Mol Med. 2016 Jan;22(1):3-4. doi: 10.1016/j.molmed.2015.11.008. Epub 2015 Dec 12.

Abstract

Dendritic cells (DCs) regulate the generation of effector adaptive immunity and enforce peripheral tolerance. In the October 2015 issue of Immunity, Zlotnikov-Klionsky et al. present exciting data describing a population of perforin-expressing CD11c(+)DCs that limit obesity as well as metabolic and autoimmune inflammation in mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autoimmunity / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Dendritic Cells / immunology*
  • Female
  • Inflammation / immunology*
  • Male
  • Metabolic Syndrome / immunology*
  • Pore Forming Cytotoxic Proteins / analysis*

Substances

  • Pore Forming Cytotoxic Proteins