A General Strategy for Facile Synthesis and In Situ Screening of Self-Assembled Polymer-Peptide Nanomaterials

Adv Mater. 2016 Mar 2;28(9):1859-67. doi: 10.1002/adma.201504564. Epub 2015 Dec 23.

Abstract

A universal strategy for efficient, mild, and purification-free synthesis and in situ screening of functional polymer-peptide nanomaterials is described. More than 1000 polymer-peptide conjugates (PPCs) with various chemical structures, compositions, and therapeutic efficacy are created. According to this strategy, the structure-function relationship of the PPCs is revealed, and the antitumor efficacies of the top performing PPCs are evaluated in vivo.

Keywords: nanomaterials; peptides; screening; self-assembly; tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chemistry Techniques, Synthetic
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Nanoparticles / chemistry*
  • Nanotechnology / methods*
  • Peptides / chemistry*
  • Peptides / pharmacology
  • Polymers / chemistry*
  • Protein Structure, Secondary

Substances

  • Peptides
  • Polymers