Type 1 Retinopathy of Prematurity and Its Laser Treatment of Large Preterm Infants in East China

PLoS One. 2015 Dec 16;10(12):e0144313. doi: 10.1371/journal.pone.0144313. eCollection 2015.

Abstract

Purpose: To describe Type 1 retinopathy of prematurity (ROP) and its laser treatment outcomes in premature infants with birth weight > 1250 g in Eastern China.

Methods: A retrospective review of 3175 ROP records was conducted at Shanghai Eye & ENT Hospital of Fudan University. The records were collected at the ROP clinic from 2006 to 2014, including their demographic and medical information such as gestational age, birth weight, supplemental oxygen therapy, systemic complications, ROP stage, location, presence of plus disease. All infants were examined by RetCam fundus camera. Those with Type 1 ROP were also examined by indirect ophthalmoscope before undergoing transpupillary laser treatment.

Results: A total of 12 infants (24 eyes) with Type 1 ROP and birth weight > 1250 g were enrolled. All infants enrolled had plus disease and ROP in zone II retina. Specifically, 16 eyes (67%) had stage 2 ROP. 8 eyes (33%) had stage 3 ROP. ROP regressed in 23 eyes (96%) following laser treatment. Partial retinal detachment developed in one eye (4%). No severe involution sequelaes or laser-related complications were recorded. Mean follow-up was 30±6 weeks.

Conclusion: Type 1 ROP may occur in large premature infants who have undergone supplemental oxygen therapy. This Type 1 ROP is mainly located in zone II retina. Laser treatment is a safe and effective intervention for these infants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • China
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Premature*
  • Laser Therapy* / methods
  • Male
  • Retinopathy of Prematurity / diagnosis
  • Retinopathy of Prematurity / therapy*
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome

Grants and funding

The authors thank support from National Natural Science Foundation of China, Natural Science Foundation of Shanghai Municipality, Young Fellow Grant of Shanghai Health Bureau, Young Fellow Grant of Fudan University, China State Scholarship, Winkler Award of China Oxford Scholarship, Henry Lester Fund and Wing Yip Bursary. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.