Cardiac neuroendocrine tumour metastases: case reports and review of the literature

Nucl Med Commun. 2016 May;37(5):461-5. doi: 10.1097/MNM.0000000000000464.

Abstract

Background: Most neuroendocrine tumours (NETs) metastasize to the liver, lymph nodes and, although less frequently, to the bone. The heart is a rare localization for NET metastases.

Methods: With the introduction of the Ga-DOTATATE PET/computed tomography (CT) in our hospital as a new diagnostic method for imaging neuroendocrine tumours, more rare metastatic localizations are being found. We present six cases of patients with cardiac NET metastases detected by Ga-DOTATATE PET/CT. Also, a review of literature is presented on case reports of cardiac NET metastases in patients detected by somatostatin receptor imaging, including In-Pentetreotide single photon emission computed tomography/CT, Ga-DOTATATE PET/CT, Ga-DOTANOC PET/CT or Ga-DOTATOC PET/CT.

Results and conclusion: Most patients with cardiac NET metastases have extensive metastatic disease. The cardiac metastases are often asymptomatic.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Female
  • Heart Neoplasms / diagnostic imaging
  • Heart Neoplasms / pathology
  • Heart Neoplasms / secondary*
  • Humans
  • Male
  • Middle Aged
  • Neuroendocrine Tumors / diagnostic imaging
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / secondary*
  • Organometallic Compounds
  • Positron Emission Tomography Computed Tomography

Substances

  • Organometallic Compounds
  • gallium Ga 68 dotatate