Ovarian damage due to cyst removal: a comparison of endometriomas and dermoid cysts

Acta Obstet Gynecol Scand. 2016 Mar;95(3):285-90. doi: 10.1111/aogs.12841. Epub 2016 Jan 24.

Abstract

Introduction: Surgical treatment of endometriomas and potential damage to the ovary have been debated. Studies have described the inconsistent risk of unintended removal of ovarian tissue when a cystectomy of an endometrioma is performed. We evaluated the risk of inadvertently removed ovarian tissue during surgery by comparing specimens of endometriomas and dermoid cysts removed laparoscopically.

Material and methods: The material included 326 women in a retrospective cohort study at Rigshospitalet, University hospital in Copenhagen, Denmark from 2011 to 2013. Surgery was performed laparoscopically for 393 benign cysts with a diagnosis of either endometrioma (n = 294) or dermoid cyst (n = 99). The microscopic existence of ovarian tissue in the cystectomy specimens were compared and correlation between CA 125 and size of cysts was examined.

Results: In total, 80.3% endometrioma cystectomies disclosed ovarian stroma compared with 17.2% of the resected dermoid cysts (p < 0.001). The difference was found despite skilled laparoscopic surgeons performing the procedure in the endometriosis cohort. A significant positive correlation between the size of endometriomas and the value of CA 125 was found (p < 0.009).

Conclusion: The risk of removal of ovarian tissue during laparoscopic surgery is significantly higher for endometriomas than for dermoid cysts.

Keywords: CA 125; Endometrioma; dermoid cyst; laparoscopy; ovarian tissue; size of cyst.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • CA-125 Antigen / blood
  • Dermoid Cyst / blood
  • Dermoid Cyst / pathology*
  • Dermoid Cyst / surgery*
  • Endometriosis / blood
  • Endometriosis / pathology*
  • Endometriosis / surgery*
  • Female
  • Humans
  • Laparoscopy / adverse effects
  • Middle Aged
  • Ovarian Neoplasms / blood
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery*
  • Ovary / injuries*
  • Ovary / pathology
  • Retrospective Studies
  • Young Adult

Substances

  • CA-125 Antigen