Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients

Br J Dermatol. 2016 Mar;174(3):629-32. doi: 10.1111/bjd.14346. Epub 2016 Jan 28.

Abstract

Trichodysplasia spinulosa (TS) is a rare skin disease, caused by a specific polyomavirus, occurring in immunocompromised patients. The pathophysiological mechanisms of TS are not yet fully understood. By using polymerase chain reaction and skin biopsy immunostaining we report evidence, in a paediatric case, of follicular keratinocytes being the primary target of trichodysplasia spinulosa-associated polyomavirus.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Hair Diseases / pathology
  • Hair Diseases / virology
  • Hair Follicle / pathology
  • Hair Follicle / virology
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / adverse effects
  • Keratinocytes / virology
  • Male
  • Opportunistic Infections / complications*
  • Opportunistic Infections / pathology
  • Polyomavirus Infections / complications*
  • Polyomavirus Infections / pathology
  • Skin Diseases, Viral / complications*

Substances

  • Immunosuppressive Agents