Electrochemical comparison and biological performance of a new CoCrNbMoZr alloy with commercial CoCrMo alloy

Mater Sci Eng C Mater Biol Appl. 2016 Feb:59:346-355. doi: 10.1016/j.msec.2015.10.031. Epub 2015 Oct 22.

Abstract

A new CoCrNbMoZr alloy, with Nb and Zr content is characterized from the point of view of surface features, corrosion resistance and biological performance in order to be proposed as dental restorative material. Its properties are discussed in comparison with commercial Heraenium CE alloy based on Co, Cr and Mo as well. The microstructure of both alloys was revealed by scanning electron microscopy (SEM). The composition and thickness of the alloy native passive films were identified by X-ray photoelectron spectroscopy (XPS). The surface characteristics were analyzed by atomic force microscopy (AFM) and contact angle techniques. The quantity of ions released from alloys in artificial saliva was evaluated with inductively coupled plasma-mass spectroscopy (ICP-MS) measurements. The electrochemical stability was studied in artificial Carter-Brugirard saliva, performing open circuit potentials, polarization resistances and corrosion currents and rates. The biological performance of the new alloy was tested in vitro in terms of human adipose stem cells (hASCs) morphology, viability and proliferation status. The new alloy is very resistant to the attack of the aggressive ions from the artificial saliva. The surface properties, the roughness and wettabiliy sustain the cell behavior. The comparison of the new alloy behavior with that of existing commercial CoCrMo alloy showed the superior properties of the new metallic biomaterial.

Keywords: Adipose stem cells (hASCs); Biocompatibility; Corrosion resistance; Microstructure; New CoCrNbMoZr alloy; Surface features.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / cytology
  • Adipose Tissue / metabolism*
  • Alloys* / chemistry
  • Alloys* / pharmacology
  • Electrochemical Techniques*
  • Humans
  • Materials Testing*
  • Metals, Heavy* / chemistry
  • Metals, Heavy* / pharmacology
  • Stem Cells / cytology
  • Stem Cells / metabolism*

Substances

  • Alloys
  • Metals, Heavy