Abstract
The presence of small phospho-anions, such as PPi and ATP in protein samples often complicates the robust detection of phosphoproteins by metal-based chemosensors and receptors. We herein report the development of a bis(Zn(2+)-cyclen)-triethylbenzene scaffold which can selectively sequester PPi and ATP without affecting the detection of a di-phosphorylated peptide by a ProxyPhos chemosensor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphate / chemistry*
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Benzene Derivatives / chemistry
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Coordination Complexes / chemistry*
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Diphosphates / chemistry*
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Macrocyclic Compounds / chemistry
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Phosphopeptides / analysis*
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Zinc / chemistry
Substances
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Benzene Derivatives
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Coordination Complexes
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Diphosphates
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Macrocyclic Compounds
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Phosphopeptides
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diphosphoric acid
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Adenosine Triphosphate
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Zinc