Saggy skin as a presenting sign of angioimmunoblastic T-cell lymphoma

Clin Exp Dermatol. 2016 Jun;41(4):386-9. doi: 10.1111/ced.12773. Epub 2015 Dec 1.

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a rare, aggressive form of peripheral T-cell lymphoma that has a variety of cutaneous manifestations. To our knowledge, saggy skin has not been documented as one of these manifestations. We report a case of a patient with angioimmunoblastic T-cell lymphoma presenting initially with pruritus and saggy skin, which later progressed into erythroderma despite chemotherapy; the disease eventually resolved with autologous stem cell transplant. Appreciating the cutaneous manifestations of AITL may allow for earlier diagnosis and treatment.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use
  • Biopsy
  • Erythema / pathology
  • Foot / pathology
  • Humans
  • Immunoblastic Lymphadenopathy / pathology*
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Male
  • Pruritus
  • Skin / pathology*
  • T-Lymphocytes / physiology

Substances

  • Antineoplastic Agents