Transition-Metal-Free Self-Hydrogen-Transferring Allylic Isomerization

Org Lett. 2015 Dec 18;17(24):6102-5. doi: 10.1021/acs.orglett.5b03124. Epub 2015 Nov 30.

Abstract

Phenanthroline and tert-butoxide have been established as powerful radical initiators in reactions such as the SRN1-type coupling reactions due to the cooperation of large heteroarenes and a special feature of tert-butoxide. The first phenanthroline-tert-butoxide-catalyzed transition-metal-free allylic isomerization is described. The resulting ketones are key intermediates for indenes. The control experiments rule out the base-promoted allylic anion pathway. The radical pathway is supported by experimental evidence that includes kinetic study, kinetic isotope effect, isotope-labeling experiments, trapping experiments, and EPR experiments.

Publication types

  • Research Support, Non-U.S. Gov't