The article is devoted to pharmacoeconomic aspects of treatment of arterial hypertension including its combination with diabetes mellitus. Data of four studies of comparison of clinical and economical effectiveness of treatment with original enalapril and its fixed combination with hydrochlorothiazide with some generic preparations of enalapril are presented. It has been shown that original enalapril has advantages over generics and from position of treatment cost. It is stressed that data of pharmacoeconomic studies should be taken into consideration when determining scheme of treatment of patients with arterial hypertension.