Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease

Psychiatry Res. 2015 Dec 30;230(3):975-7. doi: 10.1016/j.psychres.2015.11.026. Epub 2015 Nov 17.

Abstract

The objective of our study was to investigate the association of two single nucleotide polymorphisms (SNPs) with genetic risk of dementia. In 212 patients with Parkinson's disease (PD), we investigated two polymorphisms within the G-protein coupled receptor kinase 5 (GRK5) gene (rs2420616, rs4752293) to determine a possible risk factor for dementia. We identified two alleles most significantly present in PD patients with dementia: G and T alleles. We also identified risk haplotypes: GC, and AT. We demonstrated that the SNPs and the related haplotypes could play a central role in predisposing PD patients to cognitive impairment.

Keywords: Dementia; GRK5; Haplotype; Polymorphism.

MeSH terms

  • Aged
  • Alleles*
  • Cognition Disorders / etiology
  • Cognition Disorders / genetics*
  • Dementia / etiology
  • Dementia / genetics*
  • Female
  • G-Protein-Coupled Receptor Kinase 5 / genetics*
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / complications
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Factors

Substances

  • G-Protein-Coupled Receptor Kinase 5
  • GRK5 protein, human