Primary pulmonary monophasic synovial sarcoma: Evading diagnosis

Asian Cardiovasc Thorac Ann. 2016 Feb;24(2):214-7. doi: 10.1177/0218492315619121. Epub 2015 Nov 26.

Abstract

Primary pulmonary synovial sarcoma is a very rare tumor, thus there is no consensus as to the most appropriate management. A 78-year-old man presented with nonspecific symptoms of weight loss and shortness of breath. Imaging confirmed a large right-sided mass and accompanying pleural effusion. Strong 18F-fluorodeoxyglucose uptake was found on positron-emission tomography. The preoperative work-up and intraoperative frozen section were inconclusive. Immunohistochemistry and molecular analysis confirmed the diagnosis of primary pulmonary monophasic synovial sarcoma.

Keywords: Immunohistochemistry; Lung neoplasms; Sarcoma; Translocation; genetic; synovial.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics
  • Fluorodeoxyglucose F18
  • Frozen Sections
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / chemistry
  • Lung Neoplasms / complications
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / surgery
  • Male
  • Molecular Diagnostic Techniques
  • Multimodal Imaging / methods
  • Pleural Effusion, Malignant / etiology
  • Pneumonectomy
  • Positron-Emission Tomography
  • Predictive Value of Tests
  • Radiopharmaceuticals
  • Sarcoma, Synovial / chemistry
  • Sarcoma, Synovial / complications
  • Sarcoma, Synovial / diagnosis*
  • Sarcoma, Synovial / genetics
  • Sarcoma, Synovial / surgery
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Biomarkers, Tumor
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18