N-terminal region of Proteus mirabilis glutathione transferase is not homologous to mammalian and plant glutathione transferases

FEBS Lett. 1989 Jun 19;250(1):57-9. doi: 10.1016/0014-5793(89)80684-2.

Abstract

The N-terminal amino acid sequence of glutathione transferase, Pm-GST-6.0, purified from Proteus mirabilis [(1988) Biochem. J. 255, 971-975] up to residue 38 and a comparative peptide fingerprint are reported. No obvious homology with the sequences of alpha, pi and mu classes of mammalian glutathione transferases as well as with those of plant glutathione transferases has been noted. These results suggest that the classification so far adopted for glutathione transferases cannot be extended to the bacterial enzyme.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Glutathione Transferase / genetics*
  • Mammals / metabolism*
  • Molecular Sequence Data
  • Plants / enzymology*
  • Plants / genetics
  • Proteus mirabilis / enzymology*
  • Proteus mirabilis / genetics
  • Species Specificity

Substances

  • Glutathione Transferase