Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?

Clin Cases Miner Bone Metab. 2015 May-Aug;12(2):135-8. doi: 10.11138/ccmbm/2015.12.2.135. Epub 2015 Oct 26.

Abstract

Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects.

Keywords: angiotensin; angiotensin receptors blockers; angiotensin-converting enzyme inhibitors; sarcopenia; skeletal muscle.

Publication types

  • Review