Secondary Vitreoretinal Lymphoma Masquerading as Acute Retinal Necrosis

Ophthalmic Surg Lasers Imaging Retina. 2015 Nov-Dec;46(10):1048-50. doi: 10.3928/23258160-20151027-11.

Abstract

Intraocular lymphoma is considered a uveitis masquerade syndrome and may rarely present with features resembling a necrotizing viral retinitis. The authors report a secondary vitreoretinal lymphoma presenting in this fashion, which was treated with a unique combination of intravitreal methotrexate and rituximab.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers, Tumor / metabolism
  • Diagnosis, Differential
  • Eye Neoplasms / diagnosis
  • Eye Neoplasms / drug therapy
  • Eye Neoplasms / secondary
  • Female
  • Flow Cytometry
  • Humans
  • Injections, Spinal
  • Intravitreal Injections
  • Lymphatic Metastasis
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / metabolism
  • Methotrexate / administration & dosage
  • Middle Aged
  • Neoplasm Proteins / metabolism
  • Retinal Necrosis Syndrome, Acute / diagnosis*
  • Retinal Neoplasms / diagnosis*
  • Retinal Neoplasms / drug therapy
  • Retinal Neoplasms / secondary
  • Rituximab / administration & dosage
  • Spinal Neoplasms / diagnosis*
  • Spinal Neoplasms / drug therapy
  • Spinal Neoplasms / pathology
  • Tomography, Optical Coherence
  • Vitreous Body / drug effects
  • Vitreous Body / pathology*

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Rituximab
  • Methotrexate