Mediastinal schwannoma with atypical localization diagnosed by endobronchial ultrasound

Clin Respir J. 2017 Nov;11(6):739-742. doi: 10.1111/crj.12410. Epub 2016 Jan 13.

Abstract

Introduction: Schwannoma is a peripheral nerve sheath tumor usually originating from the posterior mediastinum. Because schwannomas can exhibit high fluorodeoxyglucose uptake on positron emission tomography, they cannot be distinguished from malignant tumors.

Objectives: We present this case to stress the importance of endobronchial ultrasonography in the diagnosis of intrapulmonary masses with rare occurrence and different localization.

Methods: A patient was referred to our clinic for further workup of a soft tissue mass in the anterior mediastinum and diagnosed with a benign schwannoma by endobronchial ultrasonography.

Results: The diagnosis is thus largely based on pathological examination. Until today schwannomas have been diagnosed by pathology examination of lesions excised surgically for suspected malignancy.

Conclusion: This article was reported since intrapulmonary schwannoma is a very rare tumor and this was the first case of an anterior mediastinal schwannoma diagnosed by endobronchial ultrasonography.

Keywords: Anterior mediastinal tumor - EBUS - EBUS-TBNA - PET - schwannoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bronchoscopy / methods*
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration / methods
  • Female
  • Fluorodeoxyglucose F18 / metabolism
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology
  • Mediastinal Neoplasms / diagnostic imaging
  • Mediastinal Neoplasms / pathology*
  • Mediastinum / pathology
  • Neurilemmoma / diagnosis*
  • Neurilemmoma / diagnostic imaging
  • Neurilemmoma / pathology
  • Positron Emission Tomography Computed Tomography / methods
  • S100 Proteins / metabolism
  • Ultrasonography / instrumentation*

Substances

  • S100 Proteins
  • Fluorodeoxyglucose F18