Mechanical Ventilation and Bronchopulmonary Dysplasia

Abstract

Mechanical ventilation is an important potentially modifiable risk factor for the development of bronchopulmonary dysplasia. Effective use of noninvasive respiratory support reduces the risk of lung injury. Lung volume recruitment and avoidance of excessive tidal volume are key elements of lung-protective ventilation strategies. Avoidance of oxidative stress, less invasive methods of surfactant administration, and high-frequency ventilation are also important factors in lung injury prevention.

Keywords: Bronchopulmonary dysplasia; Lung-protective ventilation; Mechanical ventilation; Ventilator-associated lung injury; Volume-targeted ventilation.