Immunoglobulin G4-positive lymphoplasmacytic infiltration in a sarcoidal eyelid mass

Mod Rheumatol. 2018 May;28(3):555-558. doi: 10.3109/14397595.2015.1118791. Epub 2016 Mar 16.

Abstract

A 62-year-old woman presented with a one month history of a hard, nonmobile subcutaneous mass along the right nasojugal fold. Hematological studies showed elevated serum immunoglobulin G4 levels. Histopathological examination of the biopsy sample disclosed immunoglobulin G4-positive lymphoplasmacytic infiltration with a storiform fibrosis, vein occlusion, and epithelioid granulomas with necrosis. Systemic review corresponded to a sarcoidosis. Without treatment, the eyelid mass did not recur six months after the excisional biopsy.

Keywords: Epithelioid granuloma; Immunoglobulin G4; Sarcoidosis; Storiform fibrosis; Vein occlusion.

Publication types

  • Case Reports

MeSH terms

  • Eyelids / pathology*
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Middle Aged
  • Sarcoidosis / blood
  • Sarcoidosis / diagnosis*

Substances

  • Immunoglobulin G