Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

Maša Alečković; Yibin Kang

doi:10.1016/j.ccell.2015.10.010

Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis

Cancer Cell. 2015 Nov 9;28(5):554-556. doi: 10.1016/j.ccell.2015.10.010.

Authors

Maša Alečković¹, Yibin Kang²

Affiliations

¹ Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
² Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address: ykang@princeton.edu.

PMID: 26555172
DOI: 10.1016/j.ccell.2015.10.010

Abstract

Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues recently demonstrated that astrocyte-derived exosomal miR-19a reversibly downregulated PTEN expression in cancer cells, thereby increasing their CCL2 secretion and recruitment of myeloid cell to promote brain metastasis.

Publication types

Comment

MeSH terms

Animals
Brain Neoplasms / pathology*
Brain Neoplasms / secondary*
Exosomes / genetics*
Female
Gene Expression Regulation, Neoplastic*
Gene Silencing*
Humans
Male
MicroRNAs / genetics*
PTEN Phosphohydrolase / deficiency*
Tumor Microenvironment*

Substances

MicroRNAs
PTEN Phosphohydrolase