Abstract
The nucleosome serves as a general gene repressor by the occlusion of regulatory and promoter DNA sequences. Repression is relieved by the SWI/SNF-RSC family of chromatin-remodeling complexes. Research reviewed here has revealed the essential features of the remodeling process.
Keywords:
RSC; nucleosome; nucleosome-free region.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adenosine Triphosphate / chemistry
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Chromatin / chemistry*
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Chromatin Assembly and Disassembly*
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Chromosomal Proteins, Non-Histone
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Cryoelectron Microscopy
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Crystallography, X-Ray
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DNA / chemistry
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Histones / chemistry
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Humans
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Nucleosomes / chemistry
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Promoter Regions, Genetic
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Transcription, Genetic*
Substances
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Chromatin
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Chromosomal Proteins, Non-Histone
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Histones
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Nucleosomes
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Adenosine Triphosphate
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DNA