Abstract
The kinetics of the content of His-Phe-Arg-Trp-Pro-Gly-Pro (ACTH (6-9)PGP) and its hydrolysis products in the blood and brain of rats in the case of intranasal administration and intravenous injection of tritiated ACTH(6-9)PGP was studied. The parameters of bioavailability of ACTH(6-9)PGP administered intranasally were higher, indicating certain prospects in the intranasal application in clinical practice. We also found that the factor that determines ACTH(6-9)PGP proteolysis in experiments both in vivo and in vitro is aminopeptidases. The main products of ACTH(6-9)PGP during its metabolism in rats are short peptides and amino acids.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Intranasal
-
Administration, Intravenous
-
Adrenocorticotropic Hormone / administration & dosage
-
Adrenocorticotropic Hormone / analogs & derivatives*
-
Adrenocorticotropic Hormone / pharmacokinetics
-
Animals
-
Brain / metabolism*
-
Central Nervous System Agents / administration & dosage
-
Central Nervous System Agents / metabolism*
-
Drug Stability
-
Kinetics
-
Peptide Fragments / administration & dosage
-
Peptide Fragments / blood
-
Peptide Fragments / metabolism
-
Peptide Fragments / pharmacokinetics*
-
Proteolysis
-
Rats
-
Time Factors
Substances
-
Central Nervous System Agents
-
His-Phe-Arg-Trp-Pro-Gly-Pro
-
Peptide Fragments
-
Adrenocorticotropic Hormone