Diagnosis of intrachromosomal amplification of chromosome 21 (iAMP21) by molecular cytogenetics in pediatric acute lymphoblastic leukemia

Nicolas Duployez; Elise Boudry-Labis; Gauthier Decool; Guillaume Grzych; Nathalie Grardel; Wadih Abou Chahla; Claude Preudhomme; Catherine Roche-Lestienne

doi:10.1002/ccr3.357

Diagnosis of intrachromosomal amplification of chromosome 21 (iAMP21) by molecular cytogenetics in pediatric acute lymphoblastic leukemia

Clin Case Rep. 2015 Oct;3(10):814-6. doi: 10.1002/ccr3.357. Epub 2015 Aug 26.

Authors

Nicolas Duployez¹, Elise Boudry-Labis², Gauthier Decool³, Guillaume Grzych³, Nathalie Grardel³, Wadih Abou Chahla⁴, Claude Preudhomme⁵, Catherine Roche-Lestienne²

Affiliations

¹ Medical Cytogenetics Institute, Jeanne de Flandre Hospital Lille, France ; Laboratory of Hematology, Biology and Pathology Center Lille, France ; INSERM UMR-S 1172, Cancer Research Institute Lille, France.
² Medical Cytogenetics Institute, Jeanne de Flandre Hospital Lille, France ; INSERM UMR-S 1172, Cancer Research Institute Lille, France.
³ Laboratory of Hematology, Biology and Pathology Center Lille, France.
⁴ Pediatric Hematology Department, Jeanne de Flandre Hospital Lille, France.
⁵ Laboratory of Hematology, Biology and Pathology Center Lille, France ; INSERM UMR-S 1172, Cancer Research Institute Lille, France.

Abstract

Intrachromosomal amplification of chromosome 21 (iAMP21) defines a distinct cytogenetic subgroup of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with poor prognosis that should be investigated in routine practice. Single-nucleotide polymorphism (SNP)-array provides a useful method to detect such cases showing a highly characteristic profile.

Keywords: BCP-ALL; RUNX1; SNP-array; cytogenetics; iAMP21.

Publication types

Case Reports