Bilateral uveal melanomas with different gene expression detected with 7 years interval

Acta Ophthalmol. 2016 Feb;94(1):99-102. doi: 10.1111/aos.12857. Epub 2015 Oct 24.

Abstract

Purpose: To report a bilateral uveal melanoma detected in a micrometastasis study.

Method: Case report.

Results: At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells.

Conclusion: A case of bilateral melanoma with long-term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow-up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.

Keywords: FISH monosomy-BAP1; bilateral uveal melanoma; melanocytosis; micrometastasis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Choroid Neoplasms / diagnostic imaging
  • Choroid Neoplasms / genetics*
  • Choroid Neoplasms / pathology
  • Chromosomes, Human, Pair 3 / genetics*
  • Fluorescein Angiography
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Melanoma, Amelanotic / diagnostic imaging
  • Melanoma, Amelanotic / genetics*
  • Melanoma, Amelanotic / pathology
  • Melanosis / diagnostic imaging
  • Melanosis / genetics*
  • Melanosis / pathology
  • Monosomy / genetics*
  • Neoplasm Staging
  • Nevus, Pigmented / diagnostic imaging
  • Nevus, Pigmented / genetics*
  • Nevus, Pigmented / pathology
  • Tumor Suppressor Proteins / genetics*
  • Ubiquitin Thiolesterase / genetics*
  • Ultrasonography

Substances

  • BAP1 protein, human
  • Tumor Suppressor Proteins
  • Ubiquitin Thiolesterase